ELN318463 racemate

Research use only, not for human use.

ELN 318463 shows differential inhibition of presenilin (PS1)- and PS2-comprised γ-secretase with EC50s of 12nM and 656 nM for PS1and PS2, respectively.

ELN 318463 shows differential inhibition of presenilin (PS1)- and PS2-comprised γ-secretase with EC50s of 12nM and 656 nM for PS1and PS2, respectively. ELN318463 is 51-fold more selective for PS1. ELN 318463 racemate is the racemate of ELN 318463. ELN 318463 is an amyloid precursor protein (APP) selective γ-secretase inhibitor.(In Vitro):ELN318463 shows differential inhibition of presenilin (PS1)- and PS2-comprised γ-secretase with EC50s of 12nM and 656 nM for PS1and PS2, respectively.(In Vivo):Brain levels of ELN318463 (30 mg/kg) are 0.754 μM in FVB brains and 0.69 μM, and of ELN318463(100 mg/kg) are 2.7 μM in FVB brains and 1.87 μM in PDAPP brains.

ELN 318463 racemate; ELN318463 (racemate)

Others

Other Targets

Topoisomerase I

——

——

851599-82-1

471.8

C19H20BrClN2O3S

>98% (HPLC)

——

Clc1ccc(cc1)S(=O)(=O)N(Cc1ccc(Br)cc1)C1CCCCNC1=O

——

(-20℃)

With Ice Pack

≥ 2 years